Therapeutic Potential of Resveratrol: The in Vivo Evidence

Nat Rev Drug Discov. 2006 Jun;5(6):493-506. doi: 10.1038/nrd2060. Epub 2006 May 26.

Abstract

Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans.

Publication types

  • Review

MeSH terms

  • Aging / drug effects
  • Aging / physiology
  • Animals
  • Heart Diseases / drug therapy
  • Heart Diseases / prevention & control
  • Humans
  • Inflammation / drug therapy
  • Inflammation / prevention & control
  • Myocardial Infarction / drug therapy
  • Myocardial Infarction / prevention & control
  • Neoplasms / drug therapy
  • Neoplasms / prevention & control
  • Protective Agents / pharmacology
  • Protective Agents / therapeutic use*
  • Resveratrol
  • Stilbenes / pharmacokinetics
  • Stilbenes / pharmacology
  • Stilbenes / therapeutic use*
  • Stroke / drug therapy
  • Stroke / prevention & control

Substances

  • Protective Agents
  • Stilbenes
  • Resveratrol