Expression of the homeobox Hox-4 genes and the specification of position in chick wing development

Nature. 1991 Apr 18;350(6319):585-9. doi: 10.1038/350585a0.


The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chick Embryo
  • Cloning, Molecular
  • Extremities / embryology
  • Gene Expression / drug effects
  • Gene Library
  • Genes, Homeobox*
  • Mice
  • Molecular Sequence Data
  • Sequence Homology, Nucleic Acid
  • Tretinoin / pharmacology
  • Wings, Animal / embryology


  • Tretinoin