Evaluating function and health related quality of life in patients treated for extremity soft tissue sarcoma

Qual Life Res. 2006 Nov;15(9):1439-46. doi: 10.1007/s11136-006-0001-4. Epub 2006 May 27.


Objective: To evaluate how functional disability impacts on health related quality of life (HRQOL) of patients with extremity soft tissue sarcoma (STS) at 1 year post-surgery.

Design and setting: Survey of extremity STS patients pre-surgery and one-year post-treatment.

Participants: 100 participants who were treated for extremity STS between 2001 and 2003 at four Canadian hospitals. Patients were over 16 years, non-metastatic at diagnosis, and had limb salvage surgery.

Outcome measures: Musculoskeletal Tumor Society Rating Scale (MSTS), a measure of impairment; Toronto Extremity Salvage Score (TESS), a measure of activity limitations; Reintegration to Normal Living Index (RNL), a measure of participation restrictions; and EQ-VAS, a measure of HRQOL.

Results: After adjusting for demographic and clinical variables, impairment explained 54%, activity limitations explained 48%, and participation restrictions explained 61% of the variation in HRQOL. After adjustment, when all three functional measures were included in the model, only participation restrictions had a significant impact on HRQOL explaining 63% of the variation.

Conclusion: Impairment and activity limitations affect the daily activities a patient can perform, but it is the restriction in participation of life roles and situations that has the greatest effect on patient's HRQOL.

MeSH terms

  • Activities of Daily Living*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Canada
  • Databases, Factual
  • Disability Evaluation
  • Female
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Postoperative Period
  • Quality of Life*
  • Sarcoma / classification
  • Sarcoma / psychology*
  • Sarcoma / surgery
  • Severity of Illness Index
  • Surveys and Questionnaires