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Comparative Study
. 2006;9(3):284-92.
doi: 10.1038/sj.pcan.4500884. Epub 2006 May 30.

Germline BCL-2 Sequence Variants and Inherited Predisposition to Prostate Cancer

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Comparative Study

Germline BCL-2 Sequence Variants and Inherited Predisposition to Prostate Cancer

L R Kidd et al. Prostate Cancer Prostatic Dis. .

Abstract

Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.

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