The structure of nanotubes formed by diphenylalanine, the core recognition motif of Alzheimer's beta-amyloid polypeptide

Chem Commun (Camb). 2006 Jun 14:(22):2332-4. doi: 10.1039/b603080g. Epub 2006 Apr 13.

Abstract

Alzheimer's beta-amyloid diphenylalanine motif has previously been shown to self-assemble into discrete and extraordinary stiff nanotubes; these nanotubes were initially thought to be distinct from the single crystal structure of diphenylalanine, but it is now shown that the X-ray powder diffraction pattern of the nanotubes is identical to the simulated pattern for the single crystal structure, affording a new foundation for understanding and rationalizing the properties of this remarkable organic material.

MeSH terms

  • Amyloid beta-Peptides / chemistry*
  • Dipeptides
  • Models, Molecular
  • Molecular Conformation
  • Nanotubes / chemistry*
  • Phenylalanine / analogs & derivatives*
  • Phenylalanine / chemistry*
  • Powder Diffraction

Substances

  • Amyloid beta-Peptides
  • Dipeptides
  • phenylalanylphenylalanine
  • Phenylalanine