Susceptibility of Pseudomonads to Melaleuca Alternifolia (Tea Tree) Oil and Components

J Antimicrob Chemother. 2006 Aug;58(2):449-51. doi: 10.1093/jac/dkl200. Epub 2006 May 30.

Abstract

Objectives: Thirty isolates of Pseudomonas aeruginosa, 15 isolates of Pseudomonas putida and 11 isolates of Pseudomonas fluorescens were tested for susceptibility to tea tree oil (TTO), the essential oil of Melaleuca alternifolia, and the components terpinen-4-ol, alpha-terpineol, cineole, gamma-terpinene and rho-cymene.

Methods: MICs were determined by broth microdilution in Mueller-Hinton medium supplemented with 0.002% (v/v) Tween 80.

Results: The MIC90 of TTO for all isolates tested was 4% (v/v) or less. Susceptibility to components tested varied between species.

Conclusions: Pseudomonas spp. are susceptible to TTO and some of its components although they are less susceptible than many other bacteria tested previously.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cyclohexane Monoterpenes
  • Cyclohexanols / pharmacology
  • Cyclohexenes / pharmacology
  • Cymenes
  • Eucalyptol
  • Microbial Sensitivity Tests
  • Monoterpenes / pharmacology
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas fluorescens / drug effects*
  • Pseudomonas putida / drug effects*
  • Tea Tree Oil / chemistry
  • Tea Tree Oil / pharmacology*
  • Terpenes / pharmacology

Substances

  • Anti-Bacterial Agents
  • Cyclohexane Monoterpenes
  • Cyclohexanols
  • Cyclohexenes
  • Cymenes
  • Monoterpenes
  • Terpenes
  • 4-cymene
  • alpha-terpineol
  • gamma-terpinene
  • terpinenol-4
  • Tea Tree Oil
  • Eucalyptol