Hypercalciuria from acid load: renal mechanisms

J Nephrol. Mar-Apr 2006;19 Suppl 9:S53-61.


Excessive acid load is considered a risk factor for both Nephrolithiasis and osteoporosis. The mechanisms by which acid confer the risk involves multiple organs, and is highly complex and incompletely understood. At least one component of the acid effect is due to renal leak of calcium. This article summarizes the effect of acid on renal handling of calcium in the proximal tubule, thick ascending limb, and distal convoluted tubule.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acid-Base Equilibrium
  • Acidosis / complications*
  • Acidosis / metabolism
  • Acids / metabolism*
  • Calcium / urine*
  • Calcium Channels / metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Kidney Calculi / etiology*
  • Kidney Calculi / urine
  • Kidney Tubules / metabolism*
  • Risk Factors


  • Acids
  • Calcium Channels
  • Calcium