Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases

Cytokine Growth Factor Rev. 2006 Aug;17(4):295-304. doi: 10.1016/j.cytogfr.2006.04.004. Epub 2006 Jun 5.

Abstract

The related Axl, Sky and Mer receptor tyrosine kinases (RTKs) are increasingly being implicated in a host of discrete cellular responses including cell survival, proliferation, migration and phagocytosis. Furthermore, their ligands Gas6 and protein S are characteristically dependent on vitamin K for expression of their functions. The Gas6/Axl system is implicated in several types of human cancer as well as inflammatory, autoimmune, vascular and kidney diseases. Each member of the Axl RTK subfamily possesses distinct expression profiles as well as discrete functions. In this article, we review the knowledge so far on the intracellular signalling interactions and pathways concerning each of the Axl RTKs. In this way, we hope to gain a greater understanding of the mechanisms that set each of them apart, and that relay their associated functions.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Mice
  • Oncogene Proteins / classification
  • Oncogene Proteins / metabolism
  • Oncogene Proteins / physiology*
  • Protein S / metabolism
  • Proto-Oncogene Proteins / physiology
  • Rats
  • Receptor Protein-Tyrosine Kinases / classification
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Receptor Protein-Tyrosine Kinases / physiology*
  • Signal Transduction*
  • c-Mer Tyrosine Kinase

Substances

  • Intercellular Signaling Peptides and Proteins
  • Oncogene Proteins
  • Protein S
  • Proto-Oncogene Proteins
  • growth arrest-specific protein 6
  • MERTK protein, human
  • Receptor Protein-Tyrosine Kinases
  • axl receptor tyrosine kinase
  • c-Mer Tyrosine Kinase