Cost-effectiveness of universal influenza vaccination in a pregnant population

Obstet Gynecol. 2006 Jun;107(6):1323-9. doi: 10.1097/01.AOG.0000210225.45986.99.


Objective: The purpose of this study was to estimate whether universal influenza vaccination of pregnant women was cost-effective in the management of influenza-like illness during influenza season.

Methods: A decision analysis model was developed to investigate the cost-effectiveness of providing inactivated trivalent influenza vaccine to all pregnant women. This scenario was compared with providing supportive care only on a case-by-case basis to the unvaccinated pregnant population.

Results: Vaccination of 100% of pregnant women would save approximately 50 dollars per woman, resulting in a net gain of approximately 45 quality-adjusted hours relative to providing supportive care only.

Conclusion: Universal vaccination with inactivated trivalent influenza vaccine is cost-saving relative to providing supportive care alone in the pregnant population.

Level of evidence: III.

MeSH terms

  • Adolescent
  • Adult
  • Cost-Benefit Analysis
  • Decision Support Techniques
  • Female
  • Humans
  • Immunization Programs / economics*
  • Influenza Vaccines / economics*
  • Influenza Vaccines / supply & distribution
  • Influenza, Human / economics
  • Influenza, Human / prevention & control*
  • Monte Carlo Method
  • Orthomyxoviridae / immunology
  • Pregnancy
  • Pregnancy Complications, Infectious / economics
  • Pregnancy Complications, Infectious / prevention & control*
  • Quality-Adjusted Life Years


  • Influenza Vaccines