The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair

Nat Cell Biol. 2006 Jun;8(6):640-2. doi: 10.1038/ncb1417.


DNA polymerase kappa (pol kappa) is a member of the Y-family of DNA polymerases that are thought to function in translesion synthesis (TLS) past different types of DNA damage. Here, we show that pol kappa-deficient mouse cells have substantially reduced (but not absent) levels of nucleotide excision repair (NER) of UV damage, as measured by several methods. Our results provide evidence for an unexpected role for pol kappa in mammalian NER.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • DNA Repair*
  • DNA-Directed DNA Polymerase / deficiency
  • DNA-Directed DNA Polymerase / physiology*
  • Fibroblasts / cytology
  • Kinetics
  • Mice
  • Ultraviolet Rays / adverse effects


  • DNA-Directed DNA Polymerase
  • Polk protein, mouse