doi: 10.1038/ncb1417.
The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair
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- PMID: 16738703
- DOI: 10.1038/ncb1417
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The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair
Nat Cell Biol.
2006 Jun.
Abstract
DNA polymerase kappa (pol kappa) is a member of the Y-family of DNA polymerases that are thought to function in translesion synthesis (TLS) past different types of DNA damage. Here, we show that pol kappa-deficient mouse cells have substantially reduced (but not absent) levels of nucleotide excision repair (NER) of UV damage, as measured by several methods. Our results provide evidence for an unexpected role for pol kappa in mammalian NER.
Comment in
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Survival choices.Nat Cell Biol. 2006 Jun;8(6):547-9. doi: 10.1038/ncb0606-547. Nat Cell Biol. 2006. PMID: 16738701 No abstract available.
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