Abstract
S-adenosylmethionine is the major methyl donor in all living organisms, but it is also involved in many other reactions occurring through radical-based catalysis. The structure and function of some of these enzymes, including those involved in the synthesis of the molybdenum cofactors, biotin, lipoate, will be discussed.
MeSH terms
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Acyltransferases / chemistry
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Animals
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Biotin / chemistry
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Catalysis
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Chemistry, Pharmaceutical / methods
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Coproporphyrinogen Oxidase / chemistry
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Dimerization
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Escherichia coli / enzymology
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Free Radicals
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Humans
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Models, Chemical
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Molybdenum / metabolism
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Ribonucleotide Reductases / chemistry
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S-Adenosylmethionine / metabolism*
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S-Adenosylmethionine / physiology*
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Thioctic Acid / chemistry
Substances
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Free Radicals
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Biotin
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Thioctic Acid
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S-Adenosylmethionine
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Molybdenum
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Ribonucleotide Reductases
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Coproporphyrinogen Oxidase
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Acyltransferases
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lipoyltransferase I