Significant modification of lipid metabolism in aged persons following the treatment with a nutritive supplement containing embryonary peptides--preliminary results

Rom J Intern Med. 2005;43(1-2):133-9.


HUMANOFORT is a nutritive supplement extracted and purified from embryonated chicken eggs according to an original procedure under licence. Humanofort received the suitable consent from the Romanian Ministry of Health. The main components of Humanofort are two oligopeptides of 5,000 and 10,000 D molecular weight. 40 subjects aged 50-75 years (18 men and 22 women) consumed, daily, 4 caps of Humanofort for 60 days. The samples of blood from each subject were obtained before and after treatment. Therefore, each subject was his own control. In all subjects, after treatment, total cholesterol and LDL-cholesterol decreased approximately 30% as compared with the initial values. In 80% of patients, an increase of HDL cholesterol and a decrease of the insulin level in blood were also observed. After treatment, the cardiac risk factors (Aethna 2000 Program), such as total cholesterol/HDL and Apolipoproteins B/A were shifted towards lower range. These long-lasting modifications have an adaptative-regulatory character and seem to be produced by the growth factors contained in Humanofort.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Apolipoproteins / blood
  • Apolipoproteins / drug effects
  • Cholesterol / blood
  • Cholesterol, LDL / blood
  • Diabetes Mellitus / diet therapy
  • Dietary Supplements
  • Egg Proteins, Dietary / isolation & purification
  • Egg Proteins, Dietary / pharmacology*
  • Female
  • Humans
  • Lipid Metabolism / drug effects*
  • Male
  • Middle Aged
  • Peptides / chemistry
  • Peptides / isolation & purification
  • Peptides / pharmacology


  • Apolipoproteins
  • Cholesterol, LDL
  • Egg Proteins, Dietary
  • Peptides
  • Cholesterol