Reduction of behavioural disturbances in elderly dogs supplemented with a standardised Ginkgo leaf extract

Schweiz Arch Tierheilkd. 2006 May;148(5):257-63. doi: 10.1024/0036-7281.148.5.257.


In this open clinical trial conducted in 10 veterinary practices, Ginkgo leaf extract was administered as a dietary supplement to 42 elderly dogs (mean age 11.4 years) at a daily dose of 40 mg/ 10 kg body weight for 8 weeks. The "severity of the geriatric condition" in dogs with a history of geriatric behavioural disturbances (mean duration 12 months), was significantly reduced after 8 weeks of treatment (P = 0.0002). The positive effect was already apparent after 4 weeks. Thirty-six % of the dogs were completely free of clinical signs at study end. Overall efficacy of treatment as judged by the investigator was good or very good in 79% of the dogs. Five of six clinical sign scores (disorientation, sleep/activity changes, behavioural changes, general behaviour and general physical condition/vitality) also showed a significant decrease over the treatment period. In conclusion, these findings provide promising results that could increase the quality of life in the elderly dog and, as a consequence, that of the pet owner. The Ginkgo leaf extract appears to be an efficacious agent that provides a safe dietary supplement for the elderly dog with age-related behavioural disturbances.

MeSH terms

  • Aging / drug effects
  • Aging / psychology
  • Animals
  • Behavior, Animal / drug effects*
  • Dietary Supplements
  • Dog Diseases / drug therapy*
  • Dogs
  • Female
  • Ginkgo biloba / chemistry*
  • Male
  • Phytotherapy / veterinary*
  • Plant Extracts / administration & dosage
  • Plant Extracts / therapeutic use*
  • Plant Leaves / chemistry
  • Quality of Life
  • Treatment Outcome


  • Plant Extracts