The turnover of rat cortical alpha 1-adrenoceptors is not modified by repeated electroconvulsive treatment

J Neurochem. 1991 Jun;56(6):2004-6. doi: 10.1111/j.1471-4159.1991.tb03459.x.


The effect of repeated treatment with electroconvulsive shock (ECS) on the turnover of cortical alpha 1-adrenoceptors in rats was measured using the N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ)-induced irreversible receptor inactivation method. Repeated treatment with ECS did not affect parameters (the synthesis rate constant r, the degradation rate constant k) of alpha 1-adrenoceptor turnover. Because increase in the density of alpha 1-adrenoceptors in the ECS-treated group disappears later during measurement of turnover, several calculation possibilities were discussed. The present data confirm that repeated treatment with ECS produces a short-lasting up-regulation of cortical alpha 1-adrenoceptors, but does not affect the turnover of this receptor type.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic alpha-Antagonists / pharmacology
  • Animals
  • Cerebral Cortex / metabolism*
  • Electroshock*
  • Male
  • Osmolar Concentration
  • Prazosin / metabolism
  • Quinolines / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Adrenergic, alpha / metabolism*


  • Adrenergic alpha-Antagonists
  • Quinolines
  • Receptors, Adrenergic, alpha
  • EEDQ
  • Prazosin