Staying in shape with formins

Dev Cell. 2006 Jun;10(6):693-706. doi: 10.1016/j.devcel.2006.05.001.


Formins constitute a diverse protein family present in all eukaryotes examined. They are defined by the presence of a formin homology 2 (FH2) domain, which possesses intrinsic and conserved functions regulating cytoskeletal dynamics. Over the past few years, formins have become recognized as potent nucleators of linear actin filaments that control a large variety of cellular and morphogenetic functions. Here, we review the molecular principles of formin-induced cytoskeletal rearrangements and their consequences for a growing number of biological processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / chemistry
  • Actin Cytoskeleton / metabolism*
  • Animals
  • Contractile Proteins / metabolism
  • Humans
  • Microfilament Proteins / chemistry
  • Microfilament Proteins / physiology*
  • Models, Biological
  • Protein Binding
  • Protein Structure, Tertiary


  • Contractile Proteins
  • Microfilament Proteins