Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1

Exp Physiol. 2006 Sep;91(5):803-6. doi: 10.1113/expphysiol.2006.033498. Epub 2006 Jun 1.


Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of HIF-1alpha and HIF-1beta subunits that functions as a master regulator of oxygen homeostasis. Oxygen-dependent hydroxylation of HIF-1alpha provides a mechanism that allows changes in oxygenation to be transduced to the nucleus, leading to changes in gene expression. Hypoxia-inducible factor 1 plays critical roles in development, physiology and disease pathogenesis. Analyses of mice that are heterozygous for a null allele at the locus encoding the HIF-1alpha subunit have demonstrated that partial deficiency of HIF-1 is sufficient to impair multiple physiological responses to continuous and intermittent hypoxia.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Physiological Phenomena
  • Carotid Body / physiology
  • Embryonic Development / genetics
  • Embryonic Development / physiology
  • Gene Expression / physiology
  • Homeostasis / physiology*
  • Humans
  • Hypoxia / physiopathology*
  • Hypoxia-Inducible Factor 1 / genetics
  • Hypoxia-Inducible Factor 1 / physiology*
  • Mice
  • Oxygen / physiology
  • Pulmonary Circulation / physiology
  • Respiratory Physiological Phenomena


  • Hypoxia-Inducible Factor 1
  • Oxygen