[Antistressor effect of delta-sleep-inducing peptide in hypokinetic stress]

Ukr Biokhim Zh (1978). 1991 Jan-Feb;63(1):34-7.
[Article in Russian]

Abstract

The influence of DSIP injection on the levels of neurotransmitters during hypokinetic stress was studied. It was shown that hypokinesia produced considerable changes in the levels of GABA glutamate, aspartate and homocarnosine. The injection of DSIP normalized the level of neurotransmitter amino acids. Administration of DSIP also reduced stress-induced changes in the activity of enzymes of GABA metabolism. Stress protective effect of DSIP was also demonstrated by normalising of the POL of lipids in brain.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Aspartic Acid / drug effects
  • Aspartic Acid / metabolism
  • Brain / metabolism
  • Carnosine / analogs & derivatives
  • Carnosine / drug effects
  • Carnosine / metabolism
  • Delta Sleep-Inducing Peptide / pharmacology*
  • Glutamates / drug effects
  • Glutamates / metabolism
  • Glutamic Acid
  • Lipid Metabolism
  • Neurotransmitter Agents / metabolism*
  • Rats
  • Restraint, Physical
  • Stress, Physiological / drug therapy*
  • Stress, Physiological / enzymology
  • gamma-Aminobutyric Acid / drug effects
  • gamma-Aminobutyric Acid / metabolism

Substances

  • Glutamates
  • Neurotransmitter Agents
  • Aspartic Acid
  • homocarnosine
  • Glutamic Acid
  • gamma-Aminobutyric Acid
  • Delta Sleep-Inducing Peptide
  • Carnosine