Miltefosine: issues to be addressed in the future

Trans R Soc Trop Med Hyg. 2006 Dec;100 Suppl 1:S41-4. doi: 10.1016/j.trstmh.2006.02.009. Epub 2006 Jun 5.

Abstract

Future issues that need to be addressed for miltefosine are efficacy against non-Indian visceral leishmaniasis, efficacy in HIV-coinfected patients, efficacy against the many forms of cutaneous and mucosal disease, effectiveness under clinical practice conditions, generation of drug resistance and the need to provide a second antileishmanial agent to protect against this disastrous event, and the ability to maintain reproductive contraceptive practices under routine clinical conditions.

Publication types

  • Review

MeSH terms

  • Abnormalities, Drug-Induced / prevention & control
  • Antiprotozoal Agents / therapeutic use*
  • Drug Resistance
  • Female
  • Forecasting
  • HIV Infections / complications
  • Humans
  • Leishmaniasis / complications
  • Leishmaniasis / drug therapy*
  • Phosphorylcholine / analogs & derivatives*
  • Phosphorylcholine / therapeutic use
  • Pregnancy
  • Pregnancy Complications, Parasitic / drug therapy

Substances

  • Antiprotozoal Agents
  • Phosphorylcholine
  • miltefosine