Comorbid substance-use in schizophrenia: relation to positive and negative symptoms

Schizophr Res. 2006 Sep;86(1-3):251-5. doi: 10.1016/j.schres.2006.04.004. Epub 2006 Jun 5.


As substance use disorders (SUD) are common in schizophrenia patients, we tested the hypothesis that comorbid patients (SUD[+]) have more positive vs. negative symptoms than non-comorbid (SUD[-]) patients. From reports identified by literature-searching we compared Positive and Negative Syndrome Scale (PANSS) ratings in schizophrenia patients with and without SUD using meta-analytic methods. Among 9 comparisons (N=725 subjects), SUD[+] patients were more often men, and abused alcohol>cannabis>cocaine. SUD[+] patients had very significantly higher PANSS-positive, and lower PANSS-negative scores. Comorbid SUD in schizophrenia patients was associated with male sex and higher PANSS positive to lower negative scores. Cause-effect relationships remain to be clarified.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Comorbidity
  • Confidence Intervals
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Psychiatric Status Rating Scales
  • Schizophrenia / epidemiology*
  • Schizophrenia / physiopathology*
  • Severity of Illness Index
  • Sex Factors
  • Substance-Related Disorders / epidemiology*
  • Substance-Related Disorders / physiopathology*