Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis

J Hepatol. 2006 Nov;45(5):704-10. doi: 10.1016/j.jhep.2006.03.012. Epub 2006 Apr 25.


Background/aims: Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of PSC and the E/E genotype of the K469E polymorphism has been reported to be associated with PSC susceptibility. The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia.

Methods: Seven single nucleotide polymorphisms (SNPs) in MAdCAM-1 and the G421R and K469E ICAM-1 SNPs were genotyped in 365 PSC patients from Norway and Sweden. 327 Norwegian ulcerative colitis (UC) patients and 368 Norwegian bone marrow donors served as controls.

Results: No significant association with PSC was found for any of the MAdCAM-1 or ICAM-1 SNPs. Allele frequencies for these polymorphisms were not significantly different between PSC patients with UC, UC patients and healthy controls.

Conclusions: Polymorphisms in MAdCAM-1 are not likely to significantly affect PSC susceptibility. In addition, the E/E genotype of the K469E in ICAM-1 does not influence PSC susceptibility in Scandinavia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Cell Adhesion Molecules
  • Cholangitis, Sclerosing / genetics*
  • Cholangitis, Sclerosing / immunology
  • Genetic Predisposition to Disease
  • Humans
  • Immunoglobulins / genetics*
  • Inflammatory Bowel Diseases
  • Intercellular Adhesion Molecule-1 / genetics*
  • Linkage Disequilibrium
  • Molecular Sequence Data
  • Mucoproteins / genetics*
  • Norway
  • Odds Ratio
  • Polymorphism, Single Nucleotide / genetics*
  • Sweden


  • Cell Adhesion Molecules
  • Immunoglobulins
  • MADCAM1 protein, human
  • Mucoproteins
  • Intercellular Adhesion Molecule-1