Mitochondrial dynamics and Ca2+ signaling

Biochim Biophys Acta. May-Jun 2006;1763(5-6):442-9. doi: 10.1016/j.bbamcr.2006.04.002. Epub 2006 Apr 20.


Recent data shed light on two novel aspects of the mitochondria-Ca2+ liaison. First, it was extensively investigated how Ca2+ handling is controlled by mitochondrial shape, and positioning; a playground also of cell death and survival regulation. On the other hand, significant progress has been made to explore how intra- and near-mitochondrial Ca2+ signals modify mitochondrial morphology and cellular distribution. Here, we shortly summarize these advances and provide a model of Ca2+-mitochondria interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Calcium Signaling*
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Mitochondria / metabolism*