Sorting out Toll signals

Katherine A Fitzgerald; Zhijian J Chen

doi:10.1016/j.cell.2006.05.014

Sorting out Toll signals

Cell. 2006 Jun 2;125(5):834-6. doi: 10.1016/j.cell.2006.05.014.

Authors

Katherine A Fitzgerald¹, Zhijian J Chen

Affiliation

¹ Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. kate.fitzgerald@umassmed.edu

PMID: 16751092
DOI: 10.1016/j.cell.2006.05.014

Abstract

Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.

Publication types

Comment
Review

MeSH terms

Adaptor Proteins, Signal Transducing / metabolism
Animals
Humans
Membrane Glycoproteins / metabolism*
Membrane Lipids / metabolism*
Myeloid Differentiation Factor 88
Phosphatidylinositol 4,5-Diphosphate / metabolism*
Phospholipids / metabolism
Protein Transport / physiology
Receptors, Interleukin-1 / metabolism*
Signal Transduction / physiology*
Toll-Like Receptor 4 / metabolism
Toll-Like Receptors / metabolism*

Substances

Adaptor Proteins, Signal Transducing
MYD88 protein, human
Membrane Glycoproteins
Membrane Lipids
Myeloid Differentiation Factor 88
Phosphatidylinositol 4,5-Diphosphate
Phospholipids
Receptors, Interleukin-1
TIRAP protein, human
TLR4 protein, human
Toll-Like Receptor 4
Toll-Like Receptors