Bone formation: The nuclear matrix reloaded

Cell. 2006 Jun 2;125(5):840-2. doi: 10.1016/j.cell.2006.05.022.

Abstract

In this issue of Cell, Grosschedl and colleagues (Dobreva et al., 2006) report that the nuclear matrix protein Satb2 represses Hoxa2 expression and acts with other regulatory proteins to promote osteoblast differentiation. This work suggests a molecular mechanism that enables the integration of patterning and differentiation during bone formation.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Body Patterning / physiology
  • Bone and Bones / cytology
  • Bone and Bones / metabolism*
  • Cell Differentiation / physiology*
  • Gene Expression Regulation, Developmental / physiology
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism
  • Humans
  • Matrix Attachment Region Binding Proteins / genetics
  • Matrix Attachment Region Binding Proteins / metabolism*
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / metabolism
  • Neural Crest / cytology
  • Neural Crest / metabolism
  • Nuclear Matrix / metabolism*
  • Nuclear Matrix / ultrastructure
  • Osteoblasts / cytology
  • Osteoblasts / metabolism*
  • Osteogenesis / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Homeodomain Proteins
  • Hoxa2 protein, mouse
  • Matrix Attachment Region Binding Proteins
  • SATB2 protein, mouse
  • Transcription Factors