Quality control in self/nonself discrimination

Cell. 2006 Jun 2;125(5):845-58. doi: 10.1016/j.cell.2006.05.017.

Abstract

Unicellular eukaryotes primarily employ self/nonself discrimination to avoid self-mating, whereas multicellular organisms also use self/nonself discrimination in immune defense. Recent advances in understanding self/nonself discrimination in eukaryotes shed new light on the emergence of the most sophisticated self/nonself discrimination system known, the antigen receptors employed in the adaptive immune system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Eukaryotic Cells / immunology*
  • Evolution, Molecular
  • Fungi / immunology
  • Humans
  • Immunity, Innate / physiology*
  • Immunologic Surveillance / immunology*
  • Killer Cells, Natural / immunology
  • Peptides / immunology
  • Plants / immunology
  • Receptors, Antigen / immunology*
  • Reproduction / physiology

Substances

  • Peptides
  • Receptors, Antigen