Reduction of acid tolerance by tetracycline in Escherichia coli expressing tetA(C) is reversed by cations

Appl Environ Microbiol. 2006 Jun;72(6):4472-4. doi: 10.1128/AEM.02519-05.

Abstract

When tetracycline was present, tetA(C) reduced acid tolerance, suppressed rpoS expression, and increased the concentration of total soluble proteins in stationary-phase Escherichia coli. The suppression of acid tolerance was reversed by 85 mM sodium, potassium, magnesium, and calcium ions but not by 85 mM sucrose. Implications for using TetA(C) are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antiporters / genetics*
  • Antiporters / metabolism
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Cations / pharmacology
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Escherichia coli / growth & development
  • Escherichia coli / physiology*
  • Escherichia coli Proteins / genetics*
  • Sucrose / pharmacology
  • Tetracycline / pharmacology*

Substances

  • Antiporters
  • Bacterial Proteins
  • Cations
  • Escherichia coli Proteins
  • tetA protein, Bacteria
  • Sucrose
  • Tetracycline