CD4+ T cells and B cells are necessary for the transfer of protective immunity to Plasmodium chabaudi chabaudi

Eur J Immunol. 1991 Jun;21(6):1433-8. doi: 10.1002/eji.1830210616.


It is shown here that B cells, in addition to CD4+ T cells, are necessary for the development of protective immunity to Plasmodium chabaudi chabaudi (P. chabaudi) in mice. Reconstitution of severe combined immunodeficient (SCID) mice with immune or normal CD4+ T cells protected the majority of mice against an otherwise lethal challenge but the mice were unable to clear their parasitemias. By contrast, transfer of the same T cell populations into athymic nu/nu mice enabled the recipients to control and clear their infections, immune CD4+ T cells being most effective. Furthermore, SCID mice given CD4+ T cells from immune and normal donors simultaneously with immune B cells also could eliminate their infection. Clearance of parasitemia correlated with the presence of malaria-specific antibodies in the serum. The role of B cells and CD4+ T cells in the protective immune response to P. chabaudi is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Protozoan / immunology
  • B-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • Female
  • Immunologic Deficiency Syndromes / immunology
  • Immunotherapy, Adoptive*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Plasmodium / immunology*
  • T-Lymphocytes, Helper-Inducer / immunology*


  • Antibodies, Protozoan