Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein

Nat Genet. 2006 Jul;38(7):749-51. doi: 10.1038/ng1813. Epub 2006 Jun 4.

Abstract

We describe an Israeli Jewish Moroccan family presenting with autosomal dominant seborrhea-like dermatosis with psoriasiform elements, including enhanced keratinocyte proliferation, parakeratosis, follicular plugging, Pityrosporum ovale overgrowth and dermal CD4 lymphocyte infiltrate. We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein. ZNF750 is normally expressed in keratinocytes but not in fibroblasts and is barely detectable in CD4 lymphocytes.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Pair 17 / genetics
  • DNA-Binding Proteins / genetics*
  • Dermatitis, Seborrheic / genetics*
  • Dermatitis, Seborrheic / pathology
  • Female
  • Frameshift Mutation
  • Genes, Dominant
  • Humans
  • Israel
  • Jews / genetics
  • Male
  • Morocco / ethnology
  • Mutation
  • Pedigree
  • Transcription Factors / genetics*
  • Zinc Fingers / genetics

Substances

  • DNA-Binding Proteins
  • Transcription Factors