EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2

Genomics. 1991 May;10(1):43-50. doi: 10.1016/0888-7543(91)90482-t.


We isolated and mapped three new human homeoboxes located on chromosome 2 upstream from the reported seven HOX4 homeobox sequences. Two of them, HOX41 and HOX4H, clearly belong to the HOX gene family, in particular to homology groups 1 and 2, and possibly represent the most 5' HOX4 homeoboxes. A third homeobox 13 kb upstream from HOX41 was identified. Sequencing data show that this is the human homolog of the murine Evx-2 homeobox. Both homeoboxes are closely related to the murine Evx-1 and to the frog Xhox-3 homeoboxes. The four genes represent vertebrate homologs of Drosophila even-skipped (eve), a segmentation gene of the pair-rule class. Human EVX2 sequences belong to an active gene because they are transcribed and properly processed in cells and tissues. We have identified for the first time a homeogene of a different class at a HOX locus. These findings are relevant to the understanding of the evolution of HOX gene clusters and their regulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacterial Proteins*
  • Base Sequence
  • Chromosomes, Human, Pair 2*
  • Cloning, Molecular
  • DNA
  • DNA-Binding Proteins / genetics*
  • Drosophila / genetics
  • Drosophila Proteins*
  • Genes, Homeobox*
  • Homeodomain Proteins*
  • Humans
  • Molecular Sequence Data
  • Multigene Family
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid
  • Transcription Factors*
  • Tumor Cells, Cultured


  • Bacterial Proteins
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Homeodomain Proteins
  • Transcription Factors
  • eve protein, Drosophila
  • DNA

Associated data

  • GENBANK/M59982
  • GENBANK/M59983
  • GENBANK/M69251
  • GENBANK/M69252
  • GENBANK/M69253
  • GENBANK/M69254
  • GENBANK/M69255
  • GENBANK/M69256
  • GENBANK/M69257
  • GENBANK/M69258