Decreased expression of adhesion molecules on monocytes in recent onset IDDM

Immunology. 1991 May;73(1):123-5.

Abstract

The expression of adhesion molecules in monocytes of patients with recent onset type I diabetes was analysed. Monocytes were identified as CD14-positive cells by flow cytometry. The percentage of monocytes expression LFA-1 alpha, ICAM-1 and HLA-DR was slightly lower in recent onset type I diabetes (n = 13) compared to normal subjects (n = 15) and was significantly decreased after activation of cells with lipopolysaccharide and interferon-gamma for 5-24 hr. Receptor densities on adhesion molecule-positive monocytes and the expression of LFA-1 beta were normal. These data indicate that monocyte trafficking is abnormal in recent onset type 1 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antigens, CD / analysis
  • Cell Adhesion Molecules / analysis*
  • Diabetes Mellitus, Type 1 / immunology*
  • Female
  • HLA-DR Antigens / analysis
  • Humans
  • Intercellular Adhesion Molecule-1
  • Lymphocyte Function-Associated Antigen-1 / analysis
  • Male
  • Monocytes / immunology*

Substances

  • Antigens, CD
  • Cell Adhesion Molecules
  • HLA-DR Antigens
  • Lymphocyte Function-Associated Antigen-1
  • Intercellular Adhesion Molecule-1