Is grand multiparity associated with an increased risk of dysglycaemia?

Diabetologia. 2006 Jul;49(7):1522-7. doi: 10.1007/s00125-006-0276-6. Epub 2006 May 11.


Aims/hypothesis: We sought to determine the risk of diabetes and IGT/IFG with grand multiparity.

Subjects, materials and methods: Women, aged > or =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a household census (response 67 and 70%, respectively), subsequently attending a biomedical examination that included an oral glucose tolerance test (58% [6198] and 69% [819]).

Results: After adjusting for age, obesity and socio-economic status, diabetes, but not IGT/IFG, was less common among women with a parity of 1 to 2 (odds ratio [OR]=0.64 [0.48-0.84]) and 3 to 4 (OR=0.72 [0.53-0.96]) than in grand multiparous women. This relationship was unrelated to past hysterectomy, use of the oral contraceptive pill or menopausal status.

Conclusions/interpretation: Grand multiparity is associated with an increased risk of diabetes but not of IGT/IFG. We postulate that parity accelerates transition from IGT/IFG to diabetes, more than it does transition from normal glucose tolerance to IGT/IFG.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Australia
  • Blood Glucose / analysis
  • Case-Control Studies
  • Contraceptive Agents, Female / adverse effects
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / etiology*
  • Diabetes, Gestational / epidemiology
  • Female
  • Glucose Intolerance / etiology*
  • Glucose Tolerance Test
  • Health Surveys
  • Humans
  • Hysterectomy / adverse effects
  • Middle Aged
  • Parity*
  • Postmenopause / blood
  • Pregnancy
  • Random Allocation
  • Risk Factors
  • Surveys and Questionnaires


  • Blood Glucose
  • Contraceptive Agents, Female