Abrupt outpatient withdrawal of medication in analgesic-abusing migraineurs

Lancet. 1991 Jun 15;337(8755):1442-3. doi: 10.1016/0140-6736(91)93129-w.

Abstract

46 migraineurs with secondary chronic daily headache were treated for medication abuse as outpatients by abrupt withdrawal of the offending drugs. The patients were supported with adequate explanation of the disorder, regular follow-up, amitriptyline (10 mg at night), and naproxen (500 mg) for relief of headache symptoms. By 6 months of follow-up 37 patients had relief from chronic headaches, and analgesic intake had become intermittent and appropriate to the original occasional migraine episodes. 6 had substantially reduced analgesic intake, but headache severity was unchanged; 2 had not managed to reduce intake and headache was unchanged; and 1 patient withdrew after the first visit.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Amitriptyline / therapeutic use
  • Analgesics / adverse effects*
  • Caffeine / adverse effects
  • Ergotamine / adverse effects*
  • Evaluation Studies as Topic
  • Female
  • Follow-Up Studies
  • Headache / chemically induced*
  • Headache / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Migraine Disorders / drug therapy*
  • Naproxen / therapeutic use
  • Outpatients
  • Substance Withdrawal Syndrome / prevention & control*
  • Substance-Related Disorders / complications*

Substances

  • Analgesics
  • Amitriptyline
  • Caffeine
  • Naproxen
  • Ergotamine