Identification of the causes of persistent hyperuricaemia

Lancet. 1991 Jun 15;337(8755):1461-3. doi: 10.1016/0140-6736(91)93141-u.


Accurate identification of the factors that contribute to hyperuricaemia in an individual may enable some of these factors to be modified, and lead to permanent correction of the hyperuricaemia. A protocol is described which can supplement clinical assessment. Measurement of the effects on serum urate and urinary urate excretion of a low-purine diet for 7 days facilitates the identification of the contributions made by urate production (either endogenous or from purine consumption) and renal underexcretion of urate (either as a low urate clearance in the absence of renal disease or due to renal glomerular insufficiency).

MeSH terms

  • Humans
  • Kidney Diseases / blood
  • Kidney Diseases / complications*
  • Kidney Diseases / urine
  • Metabolic Diseases / blood
  • Metabolic Diseases / diet therapy
  • Metabolic Diseases / etiology*
  • Metabolic Diseases / urine
  • Purines / administration & dosage*
  • Time Factors
  • Uric Acid / blood*
  • Uric Acid / urine


  • Purines
  • Uric Acid