Plasma cell leukemia presenting with diplopia due to unilateral abducens paralysis and complex chromosomal abnormalities

Intern Med. 2006;45(9):637-40. doi: 10.2169/internalmedicine.45.1545. Epub 2006 Jun 1.


Involvement of cranial nerves is rare in plasma cell leukemia (PCL). Here, we report a case of PCL presenting with unilateral abducens paralysis. Cranial magnetic resonance imaging (MRI) disclosed a mass in the sphenoid sinus. Although the patient showed an initial response to chemotherapy, he died of disease progression 5 months later. Cytogenetic analysis showed translocation of chromosomes 11 and 14, t(11;14) (q13;q32), with additional complex abnormalities. This case implies an association between clinical manifestations and chromosomal abnormalities.

Publication types

  • Case Reports

MeSH terms

  • Abducens Nerve Diseases / complications*
  • Aged
  • Chromosome Aberrations*
  • Chromosomes, Human, Pair 11
  • Chromosomes, Human, Pair 14
  • Diplopia / etiology*
  • Disease Progression
  • Fatal Outcome
  • Humans
  • Leukemia, Plasma Cell / complications*
  • Leukemia, Plasma Cell / diagnosis
  • Leukemia, Plasma Cell / genetics*
  • Leukemia, Plasma Cell / physiopathology
  • Liver / diagnostic imaging
  • Magnetic Resonance Imaging
  • Male
  • Paralysis / complications*
  • Sphenoid Sinus / pathology
  • Tomography, X-Ray Computed
  • Translocation, Genetic