Abstract
One hundred and six patients with acne vulgaris of the face were treated for 10 weeks with either topical meclocycline sulfosalicylate, topical benzoyl peroxide or both preparations. A randomized, double-blind parallel group study was used. Benzoyl peroxide proved more effective than meclocycline in reducing acne lesion counts, while local side effects were more common in the benzoyl peroxide-treated patients. The combined treatment was of intermediate efficacy with fewer local side effects.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Acne Vulgaris / drug therapy*
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Acne Vulgaris / pathology
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Administration, Topical
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Adolescent
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Adult
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Anti-Infective Agents, Local / administration & dosage*
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Anti-Infective Agents, Local / adverse effects
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Anti-Infective Agents, Local / therapeutic use
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Benzoyl Peroxide / administration & dosage*
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Benzoyl Peroxide / adverse effects
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Benzoyl Peroxide / therapeutic use
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Child
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Double-Blind Method
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Drug Therapy, Combination
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Female
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Humans
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Male
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Oxytetracycline / administration & dosage
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Oxytetracycline / adverse effects
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Oxytetracycline / analogs & derivatives*
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Oxytetracycline / therapeutic use
Substances
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Anti-Infective Agents, Local
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meclocycline
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Benzoyl Peroxide
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Oxytetracycline