[In vitro effects of antiviral drugs on the reproduction of highly pathogenic influenza A/H5N1 virus strains that induce epizooty among poultry in the summer of 2005]

Vopr Virusol. 2006 Mar-Apr;51(2):20-2.
[Article in Russian]

Abstract

Commercial drugs, such as rimantadine, amantadine, rivabirine, and arbidole, are effective in suppressing the in vitro reproduction of highly pathogenic avian influenza A/H5N1 viruses. The study has used a porcine embryonic renal cell line and the highly pathogenic A/Duck/Novosibirsk/56/05 (H5N1) strain from a sick domestic duck (Anas platyrhynchos domesticus) (Chany Lake environs, Novosibirsk Region).

MeSH terms

  • Amantadine / pharmacology*
  • Animals
  • Animals, Domestic
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Disease Outbreaks*
  • Dose-Response Relationship, Drug
  • Ducks
  • Indoles / pharmacology*
  • Influenza A Virus, H5N1 Subtype / drug effects*
  • Influenza A Virus, H5N1 Subtype / physiology
  • Influenza in Birds / epidemiology
  • Influenza in Birds / virology
  • Kidney
  • Microbial Sensitivity Tests
  • Poultry
  • Ribavirin / pharmacology*
  • Rimantadine / pharmacology*
  • Siberia / epidemiology
  • Swine
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Indoles
  • Rimantadine
  • Ribavirin
  • umifenovir
  • Amantadine