Abstract
Tertiary alpha-hydroxy phosphonates have been synthesized in good yields and high enantiomeric purity (up to 99% ee) through a novel l-proline-catalyzed cross aldol reaction of alpha-keto phosphonates and ketones.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Enzyme Inhibitors / chemical synthesis*
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Hydroxy Acids / chemistry*
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Molecular Structure
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Organophosphonates / chemical synthesis*
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Stereoisomerism
Substances
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Enzyme Inhibitors
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Hydroxy Acids
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Organophosphonates