Current status of dosing and quantification of acute renal replacement therapy. Part 1: mechanisms and consequences of therapy under-delivery

Nephrology (Carlton). 2006 Jun;11(3):171-80. doi: 10.1111/j.1440-1797.2006.00572.x.


The dosing and quantification of acute renal replacement therapy has emerged as one of the most pressing issues in the management of critically-ill patients with acute kidney injury. Although there is ongoing debate as to the best marker of uraemic injury in this setting, several landmark studies have identified clearance-related expressions of acute renal replacement therapy dose as important determinants of survival. Part 1 of this review examines the factors affecting delivery of prescribed acute renal replacement therapy dose. The review continues in Part 2 and examines the implications of recent advances in this area for clinical practice.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Biomarkers
  • Critical Illness
  • Humans
  • Renal Replacement Therapy / adverse effects
  • Renal Replacement Therapy / methods*
  • Renal Replacement Therapy / standards
  • Treatment Outcome


  • Biomarkers