FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology

Biochem Biophys Res Commun. 2006 Jul 21;346(1):140-9. doi: 10.1016/j.bbrc.2006.05.113. Epub 2006 May 26.


FK506-binding proteins are the peptidyl prolyl cis-trans isomerases that are involved in various intracellular events. We characterized a novel mouse FK506-binding protein homolog, FKBP133/KIAA0674, in the developing nervous system. FKBP133 contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) and a domain homologous to FK506-binding protein motif. FKBP133 was predominantly expressed in cerebral cortex, hippocampus, and peripheral ganglia at embryonic day 18.5. FKBP133 protein was distributed in the axonal shafts and was partially co-localized with F-actin in the growth cones of dorsal root ganglion neurons (DRG). The number of filopodia was increased in the DRG neurons overexpressing FKBP133. In contrast, the overexpression of a mutant deleted the WH1 domain reduced the growth cone size and the number of filopodia. Furthermore, the neurons overexpressing FKBP133 became significantly resistant to Semaphorin-3A induced collapse response. These results suggest that FKBP133 modulates growth cone behavior with the WH1 domain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Axons / metabolism
  • Gene Expression Profiling
  • Growth Cones / drug effects*
  • Growth Cones / physiology
  • Mice
  • Molecular Sequence Data
  • Nervous System / embryology
  • Neurons / cytology
  • Sequence Alignment
  • Tacrolimus Binding Proteins / chemistry
  • Tacrolimus Binding Proteins / physiology*
  • Wiskott-Aldrich Syndrome Protein Family / chemistry
  • Wiskott-Aldrich Syndrome Protein Family / physiology*


  • FKBP133 protein, mouse
  • Wiskott-Aldrich Syndrome Protein Family
  • Tacrolimus Binding Proteins