Reactions between beta-casomorphins-7 and 5-HT2-serotonin receptors

Bull Exp Biol Med. 2005 Nov;140(5):582-4. doi: 10.1007/s10517-006-0030-6.

Abstract

Radioreceptor analysis showed that human beta-casomorphin-7 displaced 3H-spiperone from 5-HT2-serotonin receptors of the rat cerebral frontal cortex: EC50 8 +/- 1 microM. Human and bovine beta-casomorphin-7 dose-dependently blocked serotonin-induced human platelet aggregation: IC50 5 +/- 1 and 20 +/- 4 microM, respectively. It was proved that beta-casomorphins-7 act as 5-HT2-serotonin receptor antagonists; one of the mechanisms of their biological effects is presumably associated with modulation of the serotoninergic system.

MeSH terms

  • Animals
  • Cattle
  • Cerebral Cortex / drug effects
  • Dopamine Antagonists / pharmacology
  • Dose-Response Relationship, Drug
  • Endorphins / metabolism*
  • Humans
  • Inhibitory Concentration 50
  • Ketanserin / pharmacology
  • Peptide Fragments / metabolism*
  • Platelet Aggregation
  • Protein Binding
  • Rats
  • Receptors, Serotonin, 5-HT2 / metabolism*
  • Serotonin Antagonists / pharmacology
  • Spiperone / pharmacology

Substances

  • Dopamine Antagonists
  • Endorphins
  • Peptide Fragments
  • Receptors, Serotonin, 5-HT2
  • Serotonin Antagonists
  • Spiperone
  • beta-casomorphin 7
  • Ketanserin