Anorexia following the intrahypothalamic administration of amylin

Brain Res. 1991 Jan 25;539(2):352-4. doi: 10.1016/0006-8993(91)91644-g.

Abstract

The intrahypothalamic injection of rat amylin reduced feeding in schedule-fed rats for eight hours. Specificity of this anorectic response was indicated by an appropriate dose-response relationship and the absence of effect of human amylin. Amylin-induced anorexia was accompanied by alterations in neurotransmitter metabolism similar to those observed in anorectic tumor-bearing rats. These results indicate that amylin may inhibit feeding by acting directly on hypothalamic neurons to alter metabolism of neurotransmitter systems known to affect feeding behavior.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amyloid / administration & dosage
  • Amyloid / cerebrospinal fluid
  • Amyloid / pharmacology*
  • Animals
  • Appetite Depressants*
  • Brain Chemistry / drug effects
  • Calcitonin Gene-Related Peptide / pharmacology
  • Dose-Response Relationship, Drug
  • Eating / drug effects
  • Humans
  • Hypothalamus
  • Injections
  • Islet Amyloid Polypeptide
  • Male
  • Neurotransmitter Agents / metabolism
  • Rats
  • Rats, Inbred Strains
  • Species Specificity

Substances

  • Amyloid
  • Appetite Depressants
  • Islet Amyloid Polypeptide
  • Neurotransmitter Agents
  • Calcitonin Gene-Related Peptide