Circulating adipocytokines in non-diabetic and Type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development

Diabet Med. 2006 Jun;23(6):660-5. doi: 10.1111/j.1464-5491.2006.01823.x.


Aim: To determine the influence of Type 1 diabetes mellitus on circulating adipocytokines in children.

Methods: The circulating concentrations of leptin, adiponectin, resistin and tumour necrosis factor (TNF)-alpha were measured in 91 children, aged 11.1 +/- 2.7 years, with Type 1 diabetes mellitus (T1DM). Ninety-one healthy children were selected as control subjects.

Results: Body mass index-adjusted leptin concentrations were higher in the pubertal diabetic children compared with the control children. There was a significant positive correlation between leptin and daily insulin dose in the diabetic group. Circulating adiponectin concentrations were higher in the prepubertal diabetic children and were positively associated with HbA(1c). Resistin concentrations were lower in the prepubertal non-diabetic subjects compared with the pubertal non-diabetic children, whose values were higher than those of the diabetic children. TNF-alpha concentrations were similar in non-diabetic and diabetic children.

Conclusions: Circulating concentrations of adipocytokines are abnormal in Type 1 diabetic children, although the direction of change differs by cytokine. Pubertal development, in addition to insulin treatment and glycaemic control, also influences the concentrations.

MeSH terms

  • Adiponectin / blood
  • Adolescent
  • Analysis of Variance
  • Blood Glucose / analysis
  • Body Mass Index
  • Case-Control Studies
  • Child
  • Cytokines / blood*
  • Diabetes Mellitus, Type 1 / blood*
  • Diabetes Mellitus, Type 1 / drug therapy
  • Diabetes Mellitus, Type 1 / physiopathology
  • Female
  • Glycated Hemoglobin A / analysis
  • Humans
  • Insulin / blood
  • Insulin / therapeutic use*
  • Leptin / blood
  • Male
  • Puberty*
  • Resistin / blood
  • Tumor Necrosis Factor-alpha / analysis


  • Adiponectin
  • Blood Glucose
  • Cytokines
  • Glycated Hemoglobin A
  • Insulin
  • Leptin
  • Resistin
  • Tumor Necrosis Factor-alpha