Objective: To evaluate the function of transposed ovary and its affecting factors in young women with cervical cancer.
Methods: The patients of cervical cancer who were admitted into Peking University People's Hospital during September 1999 to January 2004 and underwent ovarian transposition in peritoneal cavity, were followed regularly and analyzed retrospectively. The questionnaire of climacteric symptoms and sexual activity were designed and delivered to all patients. Serum levels of estradiol and follicle-stimulating hormone (FSH) were measured and transposed ovaries were observed with B ultrasound post operation.
Results: The climacteric symptoms of patients who received transposed ovary unilaterally or bilaterally were not difference significantly at the mean follow-up times of 14.2 and 17.4 months, respectively (P > 0.05). However, of the patients who underwent adjuvant radiotherapy and/or chemotherapy post-surgery, climacteric symptoms were significantly more common (85%) than without adjuvant therapy (13%) (P < 0.05). Serum estradiol, and FSH levels and climacteric symptoms of the patients, who received adjuvant radiotherapy, had no significant difference between the ovaries transposed 2 cm above and 2 cm below anterosuperior horizontal iliac spine.
Conclusions: Transposed ovary to peritoneal cavity could preserve the function of ovary. Once the patients undergo adjuvant radiotherapy, the function of transposed ovary will be affected wherever the transposed ovary locates 2 cm above or below anterosuperior horizontal iliac spine.