Advances in vaccine stability monitoring technology

Vaccine. 2006 Aug 14;24(33-34):5977-85. doi: 10.1016/j.vaccine.2006.05.007. Epub 2006 May 19.


Electronic time-temperature indicator (eTTI) monitors can be programmed to exactly follow the stability characteristics of vaccines with a high degree of realism. The monitors have a visual output, enabling vaccine status to be assessed at a glance, and can also output more detailed statistical data. When packaged with vaccine vials in groups of about 10 vials per box, the eTTI can remain with a vaccine throughout most of the vaccine's lifetime. The monitors can detect essentially all cold-chain breaks, and can detect issues, such as inadvertent freezing, that are presently not detected by other vaccine stability monitors such as Vaccine Vial Monitors (VVM).

MeSH terms

  • Drug Stability
  • Drug Storage
  • Freezing
  • Hepatitis B Vaccines / standards
  • Poliovirus Vaccine, Oral / standards
  • Temperature
  • Vaccines / standards*


  • Hepatitis B Vaccines
  • Poliovirus Vaccine, Oral
  • Vaccines