Healthy centenarian subjects: the effect of red wine consumption on liver function tests

J Endocrinol Invest. 2005;28(11 Suppl Proceedings):120-2.


Liver function is well maintained with increasing age. The aim of our study was to investigate if long-term moderate (<or=500 ml/day) red wine consumption influences the most common laboratory tests of liver function in healthy centenarians. Wine consumption habits were classified as moderate red wine drinkers (D) (<or=500 ml/day of red wine consumption in the past and present) (no.=3 males, 16 females) and abstainers (A) who never consumed red wine or alcoholic beverages (no.=1 male, 4 females). None were heavy drinkers. Laboratory tests revealed low levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). AST was higher in A (Mean+/-SE=8.40+/-0.32 U/l) in comparison to D (Mean+/-SE=6.25+/-0.72 U/l), but this difference was not statistically significant. Total-bilirubin (Tbil), alkaline phosphatase (AlkP), gamma- glutamyltransferase (GGT) and pseudocholinesterase (CHE) were in the normal range, and there was no difference between D and A. We conclude that red wine consumption in centenarians had no negative effect on circulating liver enzyme activities.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged, 80 and over
  • Alanine Transaminase / blood
  • Alcohol Drinking / epidemiology*
  • Alkaline Phosphatase / blood
  • Aspartate Aminotransferases / blood
  • Bilirubin / blood
  • Butyrylcholinesterase / blood
  • Female
  • Humans
  • Life Style
  • Liver / physiology*
  • Male
  • Middle Aged
  • Time
  • Wine / adverse effects*
  • gamma-Glutamyltransferase / blood


  • gamma-Glutamyltransferase
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Butyrylcholinesterase
  • Alkaline Phosphatase
  • Bilirubin