The sympathetic control of blood pressure

Nat Rev Neurosci. 2006 May;7(5):335-46. doi: 10.1038/nrn1902.


Hypertension - the chronic elevation of blood pressure - is a major human health problem. In most cases, the root cause of the disease remains unknown, but there is mounting evidence that many forms of hypertension are initiated and maintained by an elevated sympathetic tone. This review examines how the sympathetic tone to cardiovascular organs is generated, and discusses how elevated sympathetic tone can contribute to hypertension.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Blood Pressure / physiology*
  • Central Nervous System / physiology*
  • Humans
  • Hypertension / pathology
  • Hypertension / physiopathology
  • Hypothalamus / physiology
  • Medulla Oblongata / physiology
  • Models, Neurological
  • Nerve Net / physiology
  • Sympathetic Nervous System / physiology*