Does intensive phototherapy produce hemolysis in newborns of 35 or more weeks gestation?

J Perinatol. 2006 Aug;26(8):498-500. doi: 10.1038/ Epub 2006 Jun 8.


Objective: Because there is some in vivo and in vitro evidence that standard phototherapy might produce hemolysis, we wished to know whether intensive phototherapy produces hemolysis.

Study design: We measured end-tidal carbon monoxide (CO) concentration corrected for ambient CO (ETCOc) in 27 newborn infants > or =35 weeks gestation receiving intensive phototherapy (average irradiance 43 microW/cm2/nm).

Results: There was a steady decrease in the mean ETCOc over the course of the phototherapy.

Conclusion: Intensive phototherapy did not produce hemolysis in infants > or =35 weeks gestation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breath Tests
  • Carbon Monoxide / analysis
  • Gestational Age
  • Hemolysis*
  • Humans
  • Infant, Newborn
  • Phototherapy / adverse effects*


  • Carbon Monoxide