Anti-dsDNA and anti-Sm antibodies do not predict damage in systemic lupus erythematosus

Lupus. 2006;15(5):285-91. doi: 10.1191/0961203306lu2302oa.

Abstract

We aimed to determine whether anti-dsDNA and anti-Sm antibodies predict damage in systemic lupus erythematosus (SLE). Five-hundred inception patients from the University of Toronto Lupus Clinic were studied. Predictors assessed for the entire study period were: (1) raised anti-dsDNA on two consecutive occasions; (2) anti-dsDNA levels (normal, mildly or highly elevated); (3) presence of antiSm on any occasion. To account for disease duration, the following were assessed at three years post-inception: raised anti-dsDNA on two consecutive occasions; anti-dsDNA levels. These predictors were correlated with the following outcomes: (1) overall SLICC/ACR Damage Index (SDI) at the end of the study period; (2) frequency of damage in the cardiovascular, neuropsychiatric, musculoskeletal and renal components of SDI; ((3) SDI at five years for the predictors assessed at three years post-inception. In the multivariate analysis, presence of anti-DNA antibodies or of anti-SM were non-significant but sex, age at SLE diagnosis, disease duration, corticosteroid use and cumulative dose were strong predictors of damage. Raised anti-dsDNA on two occasions or anti-dsDNA levels in the three years post-inception patients did not predict damage at five years. The presence and levels of anti-dsDNA and anti-Sm antibodies do not predict damage in SLE.

Publication types

  • Comparative Study

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Age Factors
  • Age of Onset
  • Antibodies, Antinuclear / analysis*
  • Antibodies, Antinuclear / classification
  • Antibodies, Antinuclear / immunology*
  • Asians
  • Blacks
  • Caribbean Region
  • Cohort Studies
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Humans
  • Lupus Erythematosus, Systemic / ethnology
  • Lupus Erythematosus, Systemic / immunology*
  • Male
  • Multivariate Analysis
  • Predictive Value of Tests
  • Prospective Studies
  • Severity of Illness Index
  • Time Factors
  • Whites

Substances

  • Adrenal Cortex Hormones
  • Antibodies, Antinuclear