A meta-analysis of cardiopulmonary resuscitation with and without the administration of thrombolytic agents

Resuscitation. 2006 Jul;70(1):31-6. doi: 10.1016/j.resuscitation.2005.11.016. Epub 2006 Jun 9.


Objective: To pool data on the role of thrombolytic agents in cardiopulmonary resuscitation (CPR) and evaluate the efficacy and safety of thrombolysis.

Materials and methods: The clinical studies in MEDLINE database from 1966 to August 2004 that studied the efficacy and safety in CPR with and without treatment with thrombolytic agents were assessed by a meta-analysis performed to evaluate the effect of the treatment.

Results: A total of eight papers evaluating the effect of thrombolysis in CPR were identified. This meta-analysis showed that thrombolytic agents significantly improved the rate of return of spontaneous circulation, 24 h survival rate, survival to discharge and long-term neurological function in patients treated with CPR (p < 0.01). However, the patients receiving thrombolysis had a risk of severe bleeding (p < 0.01).

Conclusion: Thrombolytic agents during CPR can improve the survival rate to discharge and neurological function.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cardiopulmonary Resuscitation / methods*
  • Cardiopulmonary Resuscitation / statistics & numerical data
  • Fibrinolytic Agents / therapeutic use*
  • Heart Arrest / mortality
  • Heart Arrest / therapy
  • Humans
  • Prognosis
  • Survival Rate
  • Treatment Outcome


  • Fibrinolytic Agents