Animal models of spondyloarthritis

Curr Opin Rheumatol. 2006 Jul;18(4):342-6. doi: 10.1097/01.bor.0000231900.81677.c5.


Purpose of review: The aim of this article is to review new insights into spondyloarthritis obtained in animal models during the last year.

Recent findings: HLA-B27 misfolding has been demonstrated in HLA-B27/human beta2-microglobulin transgenic rats. HLA-B27 misfolding is associated with a typical unfolded protein stress response and with an interferon-response signature. Prebiotic treatment of these rats reduced colitis and arthritis. Proteoglycan-induced spondylitis is distinct from proteoglycan-induced arthritis. Specific susceptibility loci for proteoglycan-induced spondylitis have been demonstrated. Bone morphogenetic proteins are important in new cartilage and bone formation in ankylosing enthesitis. Psoriasis and psoriatic arthritis-like disease develops in conditional double JunB/c-Jun knockout mice.

Summary: Insights into the molecular signaling pathways driving HLA-B27 associated spondylitis, autoimmune spondylitis, ankylosing enthesitis and psoriasis, resulting from animal models, identify new and specific therapeutic targets in spondyloarthritis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Genes, jun
  • HLA-B Antigens / immunology
  • Humans
  • Mice
  • Mice, Knockout
  • Psoriasis / genetics
  • Spondylitis, Ankylosing / genetics*
  • Spondylitis, Ankylosing / immunology*


  • HLA-B Antigens