Is elevated level of soluble endothelial protein C receptor a new risk factor for retinal vein occlusion?

Clin Exp Ophthalmol. 2006 May-Jun;34(4):305-11. doi: 10.1111/j.1442-9071.2006.01212.x.


Background: To evaluate the systemic and thrombophilic risk factors for retinal vein occlusion (RVO) and to determine whether the elevated level of soluble endothelial protein C receptor (sEPCR) is a risk factor for thrombosis.

Methods: In this case-control study, 56 patients with central RVO (CRVO), 26 patients with branch RVO (BRVO) and 78 healthy sex- and age-matched subjects were enrolled. Following ophthalmological examination, venous blood was analysed for glucose, lipid profile, lipoprotein (a), homocysteine, activated partial thromboplastin time, fibrinogen, factor VIII, protein C activity, protein S activity, activated protein C resistance, antithrombin III activity, lupus anticoagulant, anti-cardiolipin antibody, anti-phospholipid antibody, sEPCR, factor V Leiden mutation and prothrombin G20210A mutation.

Results: Apart from hypertension, glaucoma, lipoprotein (a), homocysteine and factor VIII, elevated levels of sEPCR were found to be a risk factor for CRVO (odds ratio, 1.02; 95% confidence interval, 1.007-1.028; P = 0.001). Patients with CRVO had significantly higher levels of sEPCR than those with BRVO and controls (respectively, 160.1 +/- 83.8, 116.8 +/- 65.2 and 111.3 +/- 60.5; P = 0.005). Moreover, 39% of patients with CRVO had levels of sEPCR more than 200 ng/mL, and only 5% of controls and 11% of patients with BRVO had similar high levels.

Conclusions: Besides known classical risk factors, elevated levels of sEPCR seem to be an important candidate risk factor for especially CRVO.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antigens, CD / blood*
  • Endothelial Protein C Receptor
  • Factor VIII / analysis
  • Female
  • Glaucoma / complications
  • Homocysteine / blood
  • Humans
  • Hypertension / complications
  • Lipoprotein(a) / blood
  • Male
  • Middle Aged
  • Odds Ratio
  • Receptors, Cell Surface / blood*
  • Retinal Vein Occlusion / blood
  • Retinal Vein Occlusion / etiology*
  • Risk Factors
  • Solubility
  • Venous Thrombosis / blood
  • Venous Thrombosis / etiology


  • Antigens, CD
  • Endothelial Protein C Receptor
  • Lipoprotein(a)
  • PROCR protein, human
  • Receptors, Cell Surface
  • Homocysteine
  • Factor VIII